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Non-Human Primate Adenovirus Model of Human Respiratory Disease

技术优势: Model for respiratory disease Cross-species adenovirus Novel viral species

详细技术说明: Adenoviruses, or double-stranded DNA viruses that naturally infect vertebrates, have been associated with clinical syndromes including conjunctivitis, hepatitis, and diarrhea. Conventionally, these viruses are thought to be species specific. A high degree of sequence relatedness however suggests that at least some adenoviral strains may be capable of infecting both human and nonhuman primates. These adenovirus can then be used to create models of human diseases in nonhuman primates. Researchers at the University of California, Davis have discovered an adenovirus from titi monkeys with the potential to infect both human and non-human primates, including both titi monkeys and common marmosets. The researchers have developed methods to detect the adenovirus infection. Furthermore, the virus has been successfully cultivated in a human lung adenocarcinoma cell line and a primary titi monkey cell line, presenting a potential human lung disease model in nonhuman primates.

*Abstract: Researchers at the University of California, Davis have developed a model of human respiratory disease using a titi monkey adenovirus.

*Principal Investigation: Name: Karen Bales
Department:

Name: Nicholas Lerche
Department:

Name: Eunice Chen
Department:

Name: Charles Chiu
Department:

其他: Related Materials
Chen EC, Yagi S, Kelly KR, et al. Cross-Species Transmission of a Novel Adenovirus Associated with a Fulminant Pneumonia Outbreak in a New World Monkey Colony. Nemerow GR, ed. PLoS Pathogens. 2011;7(7):e1002155. doi:10.1371/journal.ppat.1002155.
Yu G, Yagi S, Carrion R Jr, et al. Experimental cross-species infection of common marmosets by titi monkey adenovirus. PLoS One 2013; 8(7) e68558. doi: 10.1371/journal.pone.006558.

Tech ID/UC Case
27612/2011-441-0

Related Cases
2011-441-0

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