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Mouse Model for Human Non-Alcoholic Steatohepatitis and Steatolic Hepatocellular Carcinoma


Technology Application

This model can potentially be very useful in studying NASH and HCC.


Detailed Technology Description

The mouse model described here has been recently developed by researchers at UC San Diego. It mimics the pathology of human NASH and steatolic HCC. NASH appears within 24 weeks and HCC develops within 40 weeks. This model may be used to evaluate compounds, drugs, diet, devices, etc. that prevent or ameliorate NASH and attenuate its progression to HCC.


Application No.

10034462


Others

Related Materials

Nakagawa et al., ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development, Cancer Cell (2014)/j.ccr.2014.07.001


Tech ID/UC Case

24436/2014-361-0


Related Cases

2014-361-0


Country/Region

USA

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