AsiaIPEX is a one-stop-shop for players in the IP industry, facilitating IP trade and connection to the IP world. Whether you are a patent owner interested in selling your IP, or a manufacturer looking to buy technologies to upgrade your operation, you will find the portal a useful resource.

Back to search results

A Novel Genetic Method For Generating Gain-Of-Function Mutations

Detailed Technology Description

Scientists at UCSD have discovered methods and compositions for generating and using novel overexpression activity alleles of a gene in any organism, especially Drosophilia. Such alleles may be utilized in screening assays, and used to generate dominant-negative forms of bacterial toxins. The method of the present invention provides advantages in efficiency and speed over current methods and is not based on assumptions relating to protein domains or functions, and thus can provide recovery of mutants in unbiased fashion. Although the method was developed for use in Drosophila, it should be applicable to yeast, C. elegans, Arabidopsis and mammals. The method can be used to generate novel mutations in human genes as expressed in test systems to lead to functional determinations and identification of medically relevant partner genes. Dominant-negative forms of bacterial toxins can be designed to interfere with and neutralize natural toxins thereby providing a protective product.

Supplementary Information

Patent Number: US7193126B2
Application Number: US2002263367A
Inventor: Bier, Ethan | Guichard, Annabel | Srinivasan, Shaila
Priority Date: 1 Oct 2001
Priority Number: US7193126B2
Application Date: 1 Oct 2002
Publication Date: 20 Mar 2007
IPC Current: A01K0067033 | A61K0031255 | C12N001585
US Class: 800021 | 800013 | 800022
Assignee Applicant: The Regents of the University of California
Title: Method for generating overexpression of alleles in genes of unknown function
Usefulness: Method for generating overexpression of alleles in genes of unknown function
Summary: M1 is useful in generating in an organism a novel overexpression activity (NOVA) allele of a gene of unknown function (claimed).
Novelty: Generating in an organism a novel overexpression activity (NOVA) allele of a gene of unknown function by mutagenizing male organisms carrying the transgene-x and screening progeny for new NOVA dominant phenotypes

Industry

Biomedical

Sub Group

DNA/Gene Engineering

Application No.

7193126

Others

Additional Technologies by these Inventors

Small molecular inhibitors of hedgehog protein signaling for treating or protecting against influenza infection

Tech ID/UC Case

22709/2001-107-0

Related Cases

2001-107-0

Country/Region

USA

For more information, please click Here