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Oligosaccharide to Prevent Necrotizing Enterocolitis

Detailed Technology Description

A researcher at UC San Diego has identified a bioactive human milk oligosaccharide lacking from infant formula that inhibit key events in necrotizing enterocolitis pathogenesis.

Application No.

9675649

Others

State Of Development

Acquired in vivo data showing that human milk oligosaccharides (HMO) significantly reduce NEC in an animal disease model. Specifically, rats receiving formula without a specific HMO developed NEC with an average pathology score of 1.98. The pathology score was significantly reduced when supplemented with HMO in the range of 0.1 and 10 mg/mL, resembling the HMO concentration in rat and human milk, respectively. None of the rats that received HMO had a pathology score that was higher than the average score of rats that received formula without HMO. Breast-fed pups were not significantly different from rats that received HMO with their formula.

Related Materials

Bode L. Human Milk Oligosaccharides: Prebiotics and Beyond. Nutr Rev. 2009 Nov;67 Suppl 2:S183-91 (background review of subject).

Tech ID/UC Case

21416/2011-192-0

Related Cases

2011-192-0

Country/Region

USA

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