Oligosaccharide to Prevent Necrotizing Enterocolitis
- 详细技术说明
- A researcher at UC San Diego has identified a bioactive human milk oligosaccharide lacking from infant formula that inhibit key events in necrotizing enterocolitis pathogenesis.
- *Abstract
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Necrotizing enterocolitis (NEC) is one of the most frequent and fatal intestinal disorders of preterm infants. Nearly 10 percent of very-low-birth-weight infants develop it, and over a quarter of NEC infants will die from this disorder. The survivors are often faced with long-term neurological impairment. Formula-fed infants are at a 6-10-fold higher risk to develop NEC; several molecules in human milk are thought to be associated with NEC protection and yet despite improvements in formula composition, formula-fed infants remain at a 6- to 10-fold higher risk than breast-fed infants. Identifying the protective component in human milk could lead to the development of better options to diagnose, treat, and perhaps even prevent, this disorder.
- *IP Issue Date
- Jun 13, 2017
- *Principal Investigation
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Name: Lars Bode
Department:
- 申请号码
- 9675649
- 其他
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State Of Development
Acquired in vivo data showing that human milk oligosaccharides (HMO) significantly reduce NEC in an animal disease model. Specifically, rats receiving formula without a specific HMO developed NEC with an average pathology score of 1.98. The pathology score was significantly reduced when supplemented with HMO in the range of 0.1 and 10 mg/mL, resembling the HMO concentration in rat and human milk, respectively. None of the rats that received HMO had a pathology score that was higher than the average score of rats that received formula without HMO. Breast-fed pups were not significantly different from rats that received HMO with their formula.
Related Materials
Tech ID/UC Case
21416/2011-192-0
Related Cases
2011-192-0
- 国家/地区
- 美国
