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Genome-Wide Gene Expression Profiling, Alternative Splicing Monitoring, and Genotyping with Direct Template Annealing Oligo-Ligation

Detailed Technology Description

Scientists at UC San Diego have discovered sensitive and accurate assays for gene detection, genome-wide gene expression profiling, and alternative splice monitoring with minimal or no target-specific amplification. The technology relates to a novel approach of detecting and quantifying DNA and RNA rearrangement in cells. In particular, the technology is designed to analyze alternative RNA processing from common pre-mRNA precursors. The technique can also be extended to DNA research in detecting chromosome rearrangement and translocation. This invention provides a powerful assay to detect alternative splicing on a large scale and can be applied to discover disease-associated alternative splicing events. This technology could have broad applications in disease classification, diagnosis, and drug screening.

Supplementary Information

Patent Number: US6812005B2
Application Number: US2001779202A
Inventor: Fan, Jian Bing | Fu, Xiang Dong
Priority Date: 7 Feb 2000
Priority Number: US6812005B2
Application Date: 7 Feb 2001
Publication Date: 2 Nov 2004
IPC Current: C12Q000168
US Class: 4350912 | 43500612 | 4350911 | 436094 | 5360231 | 5360243 | 53602433 | 435006
Assignee Applicant: The Regents of the University of California Jolla | Illumina Inc.n Diego
Title: Nucleic acid detection methods using universal priming
Usefulness: Nucleic acid detection methods using universal priming
Summary: The method is used to identify a nucleotide in a genome sequence (claimed). The method is useful in identifying microorganisms, probing expression of normal and mutant genes, identifying mutant genes e.g. oncogenes, in tissue typing, matching tissue and blood samples in forensic medicine, and for exploring homology among genes from different species.
Novelty: Identifying a nucleotide at a detection position, comprising using a polymerase chain reaction and determining the nucleotide

Industry

Biomedical

Sub Group

DNA/Gene Engineering

Application No.

6812005

Others

Intellectual Property Info

See the following U.S. patents.

6,812,005 issued 2-November-2004, Nucleic Acid Detection Methods Using Universal Priming.
7,361,488 issued 22-April-2008, Nucleic Acid Detection Methods Using Universal Priming.

Additional Technologies by these Inventors

Tech ID/UC Case

20616/2000-095-0

Related Cases

2000-095-0

Country/Region

USA

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