Improved Perfusion Imaging Using MRI With Velocity-Selective Arterial Spin Labeling Without Spatial Selectivity
The potential applications include screening, real-time evaluations, and post-event clinical analysis for: Diagnostic imaging for stroke and other cerebrovascular diseases. Evaluation of perfusion deficits in brain disorders, such as Alzheimer’s disease and schizophrenia. Functional brain imaging. Myocardial ischemia. Ischemic diseases in other organs such as kidney, lung, and muscle. The improvement is adaptable to all commercial MRI scanners and does not require the injection of external contrast agents. Additionally, it can be developed either as a stand-alone software product added to an MRI to expand its use in the stroke market or integrated into the MRI by the manufacturers.
Inventors at UC San Diego have improved the time of tracer delivery in non-vessel selective ALS by using velocity-selective tagging. Nearly all arterial blood can be tagged irrespective of the location, bringing the tag much closer to the target tissues. The benefits of the invention are quantitative, non-invasive, clinical evaluation of brain perfusion with whole brain coverage and insensitivity to delayed perfusion.
Patent Number: US7587233B2
Application Number: US2003514084A
Inventor: Wong, Eric C. | Liu, Thomas
Priority Date: 13 May 2002
Priority Number: US7587233B2
Application Date: 16 Jun 2005
Publication Date: 8 Sep 2009
IPC Current: A61B000505 | G01R0033563
US Class: 600419 | 600410
Assignee Applicant: The Regents of the University of California
Title: Velocity-selective arterial spin labeling without spatial selectivity
Usefulness: Velocity-selective arterial spin labeling without spatial selectivity
Summary: Used for magnetic arterial spin labeling in magnetic resonance imaging employed in the treatment of cerebrovascular disease, Alzheimer's disease and schizophrenia, myocardial ischemia.
Novelty: Magnetic arterial spin labeling method for magnetic resonance imaging, involves obtaining information on perfusion by applying radio frequency pulse train to selectively tag spins based on spin velocities
Biomedical
Medical Imaging
7587233
Patent Information See issued U.S. patent #7,587,233. Related Materials Wong EC, Cronin M, Wu WC, Inglis B, Frank LR, Liu TT. Velocity-Selective Arterial Spin Labeling. Magn Reson Med. 2006 Jun;55(6):1334-41. Tech ID/UC Case 19977/2001-175-0 Related Cases 2001-175-0
Wu W, Wong E. The Effects of Water Diffusion and Laminar Flow on Velocity-Selective Arterial Spin Labeling. Conf Proc IEEE Eng Med Biol Soc. 2004; 3:1884-7.
Wu W, Wong E. Intravascular Effect in Velocity-Selective Arterial Spin Labeling. Conf Proc IEEE Eng Med Biol Soc. 2005; 6:5790-3.
Wu WC, Wong EC. Feasibility of Velocity Selective Arterial Spin Labeling in Functional MRI. J Cereb Blood Flow Metab. 2007 Apr;27(4):831-8. Epub 2006 Aug 16.
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