Improved Perfusion Imaging Using MRI With Velocity-Selective Arterial Spin Labeling Without Spatial Selectivity
- 技术应用
- The potential applications include screening, real-time evaluations, and post-event clinical analysis for: Diagnostic imaging for stroke and other cerebrovascular diseases. Evaluation of perfusion deficits in brain disorders, such as Alzheimer’s disease and schizophrenia. Functional brain imaging. Myocardial ischemia. Ischemic diseases in other organs such as kidney, lung, and muscle. The improvement is adaptable to all commercial MRI scanners and does not require the injection of external contrast agents. Additionally, it can be developed either as a stand-alone software product added to an MRI to expand its use in the stroke market or integrated into the MRI by the manufacturers.
- 详细技术说明
- Inventors at UC San Diego have improved the time of tracer delivery in non-vessel selective ALS by using velocity-selective tagging. Nearly all arterial blood can be tagged irrespective of the location, bringing the tag much closer to the target tissues. The benefits of the invention are quantitative, non-invasive, clinical evaluation of brain perfusion with whole brain coverage and insensitivity to delayed perfusion.
- *Abstract
-
Aerial spin labeling (ASL) is a powerful MRI technique for non-invasive perfusion imaging of the brain and other organs using arterial blood water as the endogenous contrast agent. However, the conventional spatially and non-vessel selective ASL methods are problematic in that the life of the tracer is shorter than the time of delivery of the tagged blood to the target tissue. The delivery time arises from variations in the distances and flow velocities along the vascular tree from the tagging location to the tissues of interest. The deliver time to the target tissue in pathological cases can be much longer then in healthy subjects. In the important application of stroke, this can lead to false positive findings of low perfusion when, in fact, perfusion is present via collateral routes of circulation.
- *IP Issue Date
- Sep 8, 2009
- *Principal Investigation
-
Name: Thomas Liu
Department:
Name: Thomas Liu
Department:
Name: Eric Wong
Department:
Name: Eric Wong
Department:
- 附加资料
- Patent Number: US7587233B2
Application Number: US2003514084A
Inventor: Wong, Eric C. | Liu, Thomas
Priority Date: 13 May 2002
Priority Number: US7587233B2
Application Date: 16 Jun 2005
Publication Date: 8 Sep 2009
IPC Current: A61B000505 | G01R0033563
US Class: 600419 | 600410
Assignee Applicant: The Regents of the University of California
Title: Velocity-selective arterial spin labeling without spatial selectivity
Usefulness: Velocity-selective arterial spin labeling without spatial selectivity
Summary: Used for magnetic arterial spin labeling in magnetic resonance imaging employed in the treatment of cerebrovascular disease, Alzheimer's disease and schizophrenia, myocardial ischemia.
Novelty: Magnetic arterial spin labeling method for magnetic resonance imaging, involves obtaining information on perfusion by applying radio frequency pulse train to selectively tag spins based on spin velocities
- 主要类别
- 生物医学
- 细分类别
- 医学影像
- 申请号码
- 7587233
- 其他
-
Patent Information
See issued U.S. patent #7,587,233.
Related Materials
Wong EC, Cronin M, Wu WC, Inglis B, Frank LR, Liu TT. Velocity-Selective Arterial Spin Labeling. Magn Reson Med. 2006 Jun;55(6):1334-41.
Wu W, Wong E. The Effects of Water Diffusion and Laminar Flow on Velocity-Selective Arterial Spin Labeling. Conf Proc IEEE Eng Med Biol Soc. 2004; 3:1884-7.
Wu W, Wong E. Intravascular Effect in Velocity-Selective Arterial Spin Labeling. Conf Proc IEEE Eng Med Biol Soc. 2005; 6:5790-3.
Wu WC, Wong EC. Feasibility of Velocity Selective Arterial Spin Labeling in Functional MRI. J Cereb Blood Flow Metab. 2007 Apr;27(4):831-8. Epub 2006 Aug 16.Tech ID/UC Case
19977/2001-175-0
Related Cases
2001-175-0
- 国家/地区
- 美国
