Amide Inhibitors of Human Secreted Phospholipase A2

Potential drugs for the treatment of MS and spinal cord injuries. High degree of specificity respectively for the sPLA2.

UC San Diego researchers have developed novel amide compounds for the treatment of inflammation. The new molecules are potent inhibitors of secreted PLA2 (sPLA2).

Patent Number: US8759392B2
Application Number: US2010994136A
Inventor: Dennis, Edward A. | Kokotos, George | Constantinou-Kokotou, Violetta | David, Samuel
Priority Date: 24 Jul 2008
Priority Number: US8759392B2
Application Date: 20 Jan 2011
Publication Date: 24 Jun 2014
IPC Current: A61K0031225
US Class: 514547 | 554036
Assignee Applicant: The Regents of the University of California
Title: Amides as inhibitors of human secreted phospholipase A2
Usefulness: Amides as inhibitors of human secreted phospholipase A2
Summary: (I) are useful for treating inflammatory conditions.
Novelty: New substituted amide compounds are secreted phospholipase A2 inhibitors useful for treating inflammatory conditions

Biomedical

Pathogen

8759392

State Of Development

This technology is offered exclusively or nonexclusively in the U.S. and/or worldwide territories. A commercial sponsor for potential future research is sought.

Related Materials

Antonopoulou, G., Barbayianni, E., Magrioti, V., Cotton, N., Stephens, D., Constantinou-Kokotou,V., Dennis, E.A. and Kokotos, G., Structure-Activity Relationships of Natural and Non-Natural Amino Acid-Based Amide and 2-Oxoamide Inhibitors of Human Phospholipase A2 Enzymes, Bioorg.Med.Chem., 16, 10257-10269 (2008).

Related Technologies

• Selective Phospholipase A2 Inhibitors of Neurological Diseases

Additional Technologies by these Inventors

• Selective Phospholipase A2 Inhibitors of Neurological Diseases

Tech ID/UC Case

19410/2009-002-0

Related Cases

2009-002-0

USA

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