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Amide Inhibitors of Human Secreted Phospholipase A2

技術優勢: Potential drugs for the treatment of MS and spinal cord injuries. High degree of specificity respectively for the sPLA2.

詳細技術說明: UC San Diego researchers have developed novel amide compounds for the treatment of inflammation. The new molecules are potent inhibitors of secreted PLA2 (sPLA2).

*Abstract: Recent studies have revealed an important role for the enzyme phospholipase A2 (PLA2) in various aspects of inflammation in the peripheral and central nervous system. PLA2 consists of a superfamily of enzymes involved in the turnover of phospholipids; their metabolic products can induce both inflammation and demyelination. Therefore, PLA2 enzymes are good candidates as drug targets for the treatment.

*IP Issue Date: Jun 24, 2014

*Principal Investigation: Name: Violetta Constantinou-Kokotou
Department:

Name: Samuel David
Department:

Name: Edward Dennis
Department:

Name: George Kokotos
Department:

附加資料: Patent Number: US8759392B2
Application Number: US2010994136A
Inventor: Dennis, Edward A. | Kokotos, George | Constantinou-Kokotou, Violetta | David, Samuel
Priority Date: 24 Jul 2008
Priority Number: US8759392B2
Application Date: 20 Jan 2011
Publication Date: 24 Jun 2014
IPC Current: A61K0031225
US Class: 514547 | 554036
Assignee Applicant: The Regents of the University of California
Title: Amides as inhibitors of human secreted phospholipase A2
Usefulness: Amides as inhibitors of human secreted phospholipase A2
Summary: (I) are useful for treating inflammatory conditions.
Novelty: New substituted amide compounds are secreted phospholipase A2 inhibitors useful for treating inflammatory conditions

主要類別: 生物醫學

細分類別: 病原

申請號碼: 8759392

其他

State Of Development

This technology is offered exclusively or nonexclusively in the U.S. and/or worldwide territories. A commercial sponsor for potential future research is sought.

Related Materials

Antonopoulou, G., Barbayianni, E., Magrioti, V., Cotton, N., Stephens, D., Constantinou-Kokotou,V., Dennis, E.A. and Kokotos, G., Structure-Activity Relationships of Natural and Non-Natural Amino Acid-Based Amide and 2-Oxoamide Inhibitors of Human Phospholipase A2 Enzymes, Bioorg.Med.Chem., 16, 10257-10269 (2008).

Related Technologies

Selective Phospholipase A2 Inhibitors of Neurological Diseases

Additional Technologies by these Inventors

Selective Phospholipase A2 Inhibitors of Neurological Diseases

Tech ID/UC Case

19410/2009-002-0

Related Cases

2009-002-0

國家/地區: 美國

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