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Monoclonal Antibody Against Cer164 (Clone 11)

Technology Benefits

Specific antibody to detect Cep164 by antibody-antigen complex formation.

Technology Application

Immunocytochemistry/immunofluorescence Immunoprecipitation Western blot

Detailed Technology Description

Centrosomal protein 164kDa (Cep164) is involved in a number of cellular pathways. It is important for microtubule organization and maintenance for the formation of primary cilia. Additionally, Cep164 is critical for G2/M checkpoint and nuclear divisions. Cep164 is also involved in DNA damage-activated ATR/ATM signaling through proper phosphorylation of H2AX, RPA, CHK2, and CHK1. Furthermore, by modulating MDC1, RPA, and CHK1, Cep164 is a mediator that maintains genomic stability critical for chromosomal segregation. The described mouse monoclonal IgG1 antibody binds to human Cep164 and has been described for use in immunocytochemistry/immunofluorescnece, immunoprecipitation, and western blot. The antibodies were derived from GST-Cep164 fusions proteins consisting of amino acids 1-196, 665-873, and 887-1187 of Cep164 and amino acids 1-107 of ATRIP.

Others

Related Materials

Sivasubramaniam S1, Sun X, Pan YR, Wang S, Lee EY., Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1., Genes Dev. 2008 Mar 1;22(5):587-600

Additional Technologies by these Inventors

Tech ID/UC Case

25548/2011-387-0

Related Cases

2011-387-0

Country/Region

USA

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