Colloidal Supports For Neuron Culture, Synthetic Networks And Transplantation
1). Studying neuronal circuit formation and dynamics:? Neurons can be manipulated genetically and mechanically.? Neurons can be assembled into ordered 2D layers and 3D networks.? Beads coated with chemical guidance can cues direct neuronal growth and promote synapse formation.? Network connectivity can be monitored remotely.2). Conducting neuron-based drug screens:? Individual beads or layered neural networks can be used as platforms for drug screens.3). Exploring therapeutic strategies:? Neurons grown on silica beads could be manipulated and used for cell replacement therapies: ideally, the intact nervous system.
1). Studying neuronal circuit formation and dynamics:? Neurons can be manipulated genetically and mechanically.? Neurons can be assembled into ordered 2D layers and 3D networks.? Beads coated with chemical guidance can cues direct neuronal growth and promote synapse formation.? Network connectivity can be monitored remotely.2). Conducting neuron-based drug screens:? Individual beads or layered neural networks can be used as platforms for drug screens.3). Exploring therapeutic strategies:? Neurons grown on silica beads could be manipulated and used for cell replacement therapies: ideally, the intact nervous system.
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Inventor: Gelfand, Erwin W. | Lucas, Joseph J.
Priority Number: US7160681B2
IPC Current: C12Q000168 | G01N003350 | G01N0033574
US Class: 43500614 | 435006 | 43500723
Assignee Applicant: National Jewish Medical and Research Centernver
Title: Method for regulating cell growth and assays related thereto
Usefulness: Method for regulating cell growth and assays related thereto
Summary: The method is used to diagnose and stage tumors, also to monitor their progression or treatment. Compounds that increase activity or expression of cdk6 are useful for treating cancer and lymphoproliferative diseases, or to protect subjects at risk of developing such diseases.
Novelty: Diagnosis, staging and monitoring of tumor growth, by detecting reduced cdk6 activity or expression, also treatment by increasing cdk6 activity
Disease Diagnostic/Treatment
Cancer/Tumor
9080148
Related Materials Tech ID/UC Case 17976/2008-121-0 Related Cases 2008-121-0
USA
