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Mitochondrial Targeted Nanoparticles that Knockdown CaMKII Activity

Detailed Technology Description

Researchers have found a composition to deliver a peptide to the mitochondria of targeted cells to inhibit the activity of CaMKII. The core of the composition is PAMAM, a microparticulate carrier providing several points of attachment for the other components of the composition, a mitochondrial targeting sequence (MLS) and a 21 monomer CaMKII inhibitory peptide.This therapy is believed to protect cells experiencing an ischemic-reperfusion event by preventing the CaMKII-mediated phosphorylation and activation of the mitochondrial calcium uniporter (MCU). MCU normally functions to maintain calcium homeostasis and its malfunction during ischemia is thought to play a key role in the resulting apoptotic cell loss. It may also be effective in the treatment of cancer, metabolic diseases and neurodegenerative diseases through the inhibition of CaMKII and MCU.

Country/Region

USA

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