Mitochondrial Targeted Nanoparticles that Knockdown CaMKII Activity
Researchers have found a composition to deliver a peptide to the mitochondria of targeted cells to inhibit the activity of CaMKII. The core of the composition is PAMAM, a microparticulate carrier providing several points of attachment for the other components of the composition, a mitochondrial targeting sequence (MLS) and a 21 monomer CaMKII inhibitory peptide.This therapy is believed to protect cells experiencing an ischemic-reperfusion event by preventing the CaMKII-mediated phosphorylation and activation of the mitochondrial calcium uniporter (MCU). MCU normally functions to maintain calcium homeostasis and its malfunction during ischemia is thought to play a key role in the resulting apoptotic cell loss. It may also be effective in the treatment of cancer, metabolic diseases and neurodegenerative diseases through the inhibition of CaMKII and MCU.
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