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Recombinant Human Follicle Stimulating Hormone Antagonists and Methods in Cancer Therapy
Technology Benefits
This antagonist is a competitive inhibitor of the FSH receptor.rFSH-Ant can be produced using standard molecular biology and recombinant protein technologies.May be administered by a variety of routes, including intravenously, orally, locally and transdermally.
Technology Application
Therapy for cancers that secrete or respond to FSH, such as epithelial ovarian cancer. ContraceptiveTreatment for ovarian hyperstimulation syndrome (OHSS).
Detailed Technology Description
The present invention comprises of recombinant human follicle stimulating hormone antagonist (rFSH-Ant) in which one or more N-glycosylation sites is disrupted. rFSH-Ant binds to the FSH receptor without activating it, thereby acting as a competitive...
Country/Region
USA
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