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A Prion-Like Form of CPEB and Related Compositions and Methods

Summary

Lead Inventors: Eric KandelMethods for determining whether an agent facilitates the conversion of a cytoplasmic polyadenylation element binding (CPEB) protein from its non-prion form to its prion form are described. Methods for determining the presence and amount of the prion form of CPEB protein in a cell are also proposed.The method provides a composition comprising a therapeutically effective amount of an agent that facilitates the conversion of a CPEB protein from its prion form to its non-prion form, and a pharmaceutically acceptable carrier. The method is vital in the treatment of neurodegenerative disorders, especially those that involve transmissible spongiform encephalopathies.

Detailed Technology Description

Methods for determining whether an agent facilitates the conversion of a cytoplasmic polyadenylation element binding (CPEB) protein from its non-prion form to its prion form are described. Methods for determining the presence and amount of the prion ...

Country/Region

USA

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