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A Prion-Like Form of CPEB and Related Compositions and Methods

總結: Lead Inventors: Eric KandelMethods for determining whether an agent facilitates the conversion of a cytoplasmic polyadenylation element binding (CPEB) protein from its non-prion form to its prion form are described. Methods for determining the presence and amount of the prion form of CPEB protein in a cell are also proposed.The method provides a composition comprising a therapeutically effective amount of an agent that facilitates the conversion of a CPEB protein from its prion form to its non-prion form, and a pharmaceutically acceptable carrier. The method is vital in the treatment of neurodegenerative disorders, especially those that involve transmissible spongiform encephalopathies.

詳細技術說明: Methods for determining whether an agent facilitates the conversion of a cytoplasmic polyadenylation element binding (CPEB) protein from its non-prion form to its prion form are described. Methods for determining the presence and amount of the prion ...

*Inquiry: Peter Golikov Columbia Technology Ventures Tel: (212) 854-8444 Email: TechTransfer@columbia.edu

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