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Compounds with Potential Use in Development of Medications for the Treatment of Multidrug Resistant HIV-1

Summary

Researchers at Purdue University have developed a series of non-peptide HIV-1 protease inhibitors that incorporate a basic amine function in the inhibitor structure. These compounds are novel and show enzyme inhibition and antiviral activity at subnanomolar levels. In addition, they have been shown to have potent activity against multidrug resistant HIV-1 strains and are expected to have improved metabolic stability and pharmacokinetic properties. These compounds have potential use in the pharmaceutical industry for the development of superior HIV medications and in healthcare for the treatment of HIV/AIDS.

Technology Benefits

HIV-1 protease inhibitor Potent activity against resistant strains Improved stability and pharmacokinetics

Technology Application

Pharmaceutical industry Drug development Medical/Healthcare Treatment of HIV/AIDS

Detailed Technology Description

Arun GhoshGhosh GroupPurdue Chemistry

Countries

United States

Application No.

None\

Country/Region

USA

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