Compounds with Potential Use in Development of Medications for the Treatment of Multidrug Resistant HIV-1
- 总结
- Researchers at Purdue University have developed a series of non-peptide HIV-1 protease inhibitors that incorporate a basic amine function in the inhibitor structure. These compounds are novel and show enzyme inhibition and antiviral activity at subnanomolar levels. In addition, they have been shown to have potent activity against multidrug resistant HIV-1 strains and are expected to have improved metabolic stability and pharmacokinetic properties. These compounds have potential use in the pharmaceutical industry for the development of superior HIV medications and in healthcare for the treatment of HIV/AIDS.
- 技术优势
- HIV-1 protease inhibitor Potent activity against resistant strains Improved stability and pharmacokinetics
- 技术应用
- Pharmaceutical industry Drug development Medical/Healthcare Treatment of HIV/AIDS
- 详细技术说明
- Arun GhoshGhosh GroupPurdue Chemistry
- *Abstract
-
- *Background
- HIV/AIDS is one of the top deadly diseases worldwide that is still common despite progress in healthcare. Human immunodeficiency virus (HIV) causes acquired immune deficiency syndrome (AIDS), which is a complex disease that includes gradual destruction of the immune system. Many current therapies that are available for the management of the disease are limited by their duration of action, side effect profile and toxicity, and their extensive pill burden. Hence, there is a need to find newer therapies for HIV/AIDS.
- *IP Issue Date
- None
- *IP Type
- Provisional
- *Stage of Development
- Process validation in lab
- *Web Links
- Purdue Office of Technology CommercializationPurdueInnovation and EntrepreneurshipArun GhoshGhosh GroupPurdue Chemistry
- 国家
- United States
- 申请号码
- None\
- 国家/地区
- 美国
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