Group Specific Internal Standard Technology and Labeling Strategy
Researchers at Purdue University have dramatically improved precision by developing a novel post-biosynthetic encoding concept using derived samples as internal standards. This cost-effective global derivation approach enables absolute quantification of known compounds and relative quantification of unknown compounds in most cases using a single LC-MS run.
Aniline based derivation agent labels most of the metabolites or other small moleculesAbsolute quantification of known compoundsRelative quantification of unknown compounds, no standards are necessaryMost of these compounds can be analyzed in single LC-MS run
Encoding Technology
Bindley Bioscience Center
United States
8,628,977
USA
