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Potent Small Molecule Inhibitors for HIV-1 Protease

Summary

The researchers have also developed a new generation of protease inhibitors that are exceedingly potent and maintain potency against multidrug resistant HIV-1 variants. Dr. Ghosh's laboratory has designed, synthesized, and evaluated several different series of compounds. These novel protease inhibitors show potent enzyme inhibitory, antiviral activity, and exceptional broad spectrum activity against highly cross-resistant mutant.

Technology Benefits

Decreased adverse side effectsEffective against multidrug resistant HIV-1 variants Improved bioavailabilitySuperior pharmacokinetic properties

Technology Application

Medical/HealthcarePharmaceuticalsHIV/AIDS TreatmentDrug Development

Detailed Technology Description

Arun GhoshGhosh GroupPurdue Chemistry

Countries

United States

Application No.

None

Country/Region

USA

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