Potent Small Molecule Inhibitors for HIV-1 Protease
The researchers have also developed a new generation of protease inhibitors that are exceedingly potent and maintain potency against multidrug resistant HIV-1 variants. Dr. Ghosh's laboratory has designed, synthesized, and evaluated several different series of compounds. These novel protease inhibitors show potent enzyme inhibitory, antiviral activity, and exceptional broad spectrum activity against highly cross-resistant mutant.
Decreased adverse side effectsEffective against multidrug resistant HIV-1 variants Improved bioavailabilitySuperior pharmacokinetic properties
Medical/HealthcarePharmaceuticalsHIV/AIDS TreatmentDrug Development
Arun GhoshGhosh GroupPurdue Chemistry
United States
None
美國
