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Method of Producing Chemicals

Summary

Engineering Yeast to grow on Methanol.

Technology Benefits

Environmentally friendly.
Produces chemicals from waste gases or biomass.
Affordable.
In the near-future, methanol will have a lower economic impact than alternatives such as sugar.

Technology Application

Growing yeast on methanol from landfill gas and wood/lignocellulosic waste.
Use in conjunction with other engineered pathways to produce valuable chemicals, biofuels and pharmaceuticals.

Detailed Technology Description

This invention enables the yeast S. cerevisiae to grow on methanol as a sole carbon and energy source. Six enzymes from the related organism Pichia pastoris were redesigned for expression in yeast, chemically synthesised, and transformed into S. cerevisiae for expression. These enzymes form a novel metabolic pathway that enables the conversion of methanol in S. cerevisiae peroxisomes of into existing central carbon metabolites that can be used to fuel metabolism.

Type of Cooperation

Licensing or
Research Collaboration

Application No.

PCT/2018/050029

ID No.

2016036

Country/Region

Australia

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