Method of Producing Chemicals
Engineering Yeast to grow on Methanol.
Environmentally friendly.
Produces chemicals from waste gases or biomass.
Affordable.
In the near-future, methanol will have a lower economic impact than alternatives such as sugar.
Growing yeast on methanol from landfill gas and wood/lignocellulosic waste.
Use in conjunction with other engineered pathways to produce valuable chemicals, biofuels and pharmaceuticals.
This invention enables the yeast S. cerevisiae to grow on methanol as a sole carbon and energy source. Six enzymes from the related organism Pichia pastoris were redesigned for expression in yeast, chemically synthesised, and transformed into S. cerevisiae for expression. These enzymes form a novel metabolic pathway that enables the conversion of methanol in S. cerevisiae peroxisomes of into existing central carbon metabolites that can be used to fuel metabolism.
Licensing or
Research Collaboration
PCT/2018/050029
2016036
澳洲
