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Neurotrophin NT-7 from Carp

Summary

Neurotrophins represent a family of proteins which can support the survival and differentiation of neurons from both central and peripheral nervous systems. Their potential use in the treatment of various neurodegenerative diseases is well known. These growth factors exhibit overlapping as well as distinct specificities of actions on various neuronal populations.

The invention relates to discovery of a novel nuerotrophin, named NT-7, from the fish, carp. Various evidence indicates that it represents a novel member of the neruotrophin family. NT-7 was found to be expressed in skin, heart, intestine, and brain in the adult fish. Expression of the recombinant protein enabled us to demonstrate its ability to support the survival and neuritis outgrowth of embryonic chick dorsal root ganglion neurons. This invention shed light on the treatment of nervous diseases such as Alzheimer's, Parkinson's and nerve muscle disorders.

Technology Benefits

1. A novel sequence
2. Inexpensive source of materials

Technology Application

- Treatment for neurodegenerative diseases
- Use as a bio-medical research reagent
- Development of gene products using medical therapy

Supplementary Information

Patent Number: US7022670B1
Application Number: US1998157984A
Inventor: Ip, Nancy Yuk Yu | Lai, Kwok On
Priority Date: 22 Sep 1998
Priority Number: US7022670B1
Application Date: 22 Sep 1998
Publication Date: 4 Apr 2006
IPC Current: C07K0014475 | A61K003818
US Class: 5140084 | 514012 | 5140177 | 530399
Assignee Applicant: The Hong Kong University of Science & Technology
Title: Neurotrophin NT-7 from carp
Usefulness: Neurotrophin NT-7 from carp
Summary: The essentially purified neurotrophin of Cyprinus carpio (carp), carp NT-7, is useful for the survival and neurile outgrowth of embryonic chick dorsal root ganglion neurons or for activating the receptor tyrosine kinase (Trks).
Novelty: New purified neurotrophin of Cyprinus carpio (carp), carp NT-7, with neurotrophic activity, for the survival and neurile outgrowth of embryonic chick dorsal root ganglion neurons

Industry

Chemical/Material

Sub Group

Chemical/Material Application

Application Date

22 Sep 1998

Application No.

US 09/157984

Patent Information

US 7022670

ID No.

TTC.PA.076

Country/Region

Hong Kong

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