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Neurotrophin NT-7 from Carp

總結: Neurotrophins represent a family of proteins which can support the survival and differentiation of neurons from both central and peripheral nervous systems. Their potential use in the treatment of various neurodegenerative diseases is well known. These growth factors exhibit overlapping as well as distinct specificities of actions on various neuronal populations.

The invention relates to discovery of a novel nuerotrophin, named NT-7, from the fish, carp. Various evidence indicates that it represents a novel member of the neruotrophin family. NT-7 was found to be expressed in skin, heart, intestine, and brain in the adult fish. Expression of the recombinant protein enabled us to demonstrate its ability to support the survival and neuritis outgrowth of embryonic chick dorsal root ganglion neurons. This invention shed light on the treatment of nervous diseases such as Alzheimer's, Parkinson's and nerve muscle disorders.

技術應用: - Treatment for neurodegenerative diseases
- Use as a bio-medical research reagent
- Development of gene products using medical therapy

附加資料: Patent Number: US7022670B1
Application Number: US1998157984A
Inventor: Ip, Nancy Yuk Yu | Lai, Kwok On
Priority Date: 22 Sep 1998
Priority Number: US7022670B1
Application Date: 22 Sep 1998
Publication Date: 4 Apr 2006
IPC Current: C07K0014475 | A61K003818
US Class: 5140084 | 514012 | 5140177 | 530399
Assignee Applicant: The Hong Kong University of Science & Technology
Title: Neurotrophin NT-7 from carp
Usefulness: Neurotrophin NT-7 from carp
Summary: The essentially purified neurotrophin of Cyprinus carpio (carp), carp NT-7, is useful for the survival and neurile outgrowth of embryonic chick dorsal root ganglion neurons or for activating the receptor tyrosine kinase (Trks).
Novelty: New purified neurotrophin of Cyprinus carpio (carp), carp NT-7, with neurotrophic activity, for the survival and neurile outgrowth of embryonic chick dorsal root ganglion neurons

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