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4(1H)-Quinolones Having Anti-Malarial Activity with Reduced Chemical Resistance

Technology Benefits: Potent anti-malarial activityImproved chemical resistance against multi-drug resistant (MDR) parasitesActs on both MDR parasites and drug susceptible anti-malarial strains equally well

Technology Application: antimalarial drugs

Detailed Technology Description: This invention promises a great approach to treat those affected with malaria. The compound possesses a potent EC50 against multidrug resistant malarial strains W2 (chloroquine and pyrimethamine resistant) and TM90-C2B (chloroquine, mefloquine, pyrimethamine, and atovaquone resistant). This compound also exhibits signs of reduced chemical resistance.

*Abstract: The University of South Florida has developed a compound that has displayed potent anti-malarial activity as well as improved chemical resistance against multi-drug resistant (MDR) parasites. The invention described is a 4(1H)-quinolone structure that has shown anti-malarial activity at concentrations as low as 0.15nM against the MDR Plasmodium falciparum.

Country/Region: USA

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