AsiaIPEX is a one-stop-shop for players in the IP industry, facilitating IP trade and connection to the IP world. Whether you are a patent owner interested in selling your IP, or a manufacturer looking to buy technologies to upgrade your operation, you will find the portal a useful resource.

Back to search results

Design of Enhanced Endosomal Escape Domains for Delivery of Macromolecules into Cells

Detailed Technology Description: UC San Diego researchers have designed an Endosomal Escape Domain (EED) that resulted in a significant enhancement of cytoplasmic delivery in the absence of cytotoxicity. In addition they developed an assay to measure transduction into the cytoplasm to compare and contrast PTDs/CPPs.

Application No.: 20170275650

Others: Tech ID/UC Case
24545/2015-010-0

Related Cases
2015-010-0

*Abstract: Macromolecular peptide, protein and oligonucleotide therapeutics have great potential to treat human disease; however, due to their size, they have no ability to enter cells. Peptide/Protein transduction domains (PTDs), also called cell-penetrating peptides (CPPs), promote uptake of macromolecules via endosomal macropinocytosis. However, overcoming the rate-limiting step of endosomal escape remains the major challenge.

*IP Issue Date: Sep 28, 2017

*Principal Investigator: Name: Steven Dowdy
Department:

Name: Peter Lonn
Department:

Country/Region: USA

For more information, please click Here