Design of Enhanced Endosomal Escape Domains for Delivery of Macromolecules into Cells
- 详细技术说明
- UC San Diego researchers have designed an Endosomal Escape Domain (EED) that resulted in a significant enhancement of cytoplasmic delivery in the absence of cytotoxicity. In addition they developed an assay to measure transduction into the cytoplasm to compare and contrast PTDs/CPPs.
- *Abstract
-
Macromolecular peptide, protein and oligonucleotide therapeutics have great potential to treat human disease; however, due to their size, they have no ability to enter cells. Peptide/Protein transduction domains (PTDs), also called cell-penetrating peptides (CPPs), promote uptake of macromolecules via endosomal macropinocytosis. However, overcoming the rate-limiting step of endosomal escape remains the major challenge.
- *IP Issue Date
- Sep 28, 2017
- *Principal Investigation
-
Name: Steven Dowdy
Department:
Name: Peter Lonn
Department:
- 申请号码
- 20170275650
- 其他
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Tech ID/UC Case
24545/2015-010-0
Related Cases
2015-010-0
- 国家/地区
- 美国
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