Mouse Cell Lines Mutant For Patched 1 And Patched 2
- Technology Benefits
- Ability to screen for agents that specifically target downstream components of Hedgehog signaling pathwayAllows identification of agents that modulate Hedgehog pathway activity in a cell
- Technology Application
- Screen for agents that target the Hedgehog signaling pathwayTest therapeutics targeting the Hedgehog signaling pathwayDevelopmental researchStem cell research
- Detailed Technology Description
- None
- Application No.
- WO2017019461
- Others
-
Tech ID/UC Case
25093/2015-181-0
Related Cases
2015-181-0
- *Abstract
-
In mammals, the Hedgehog (Hh) family of proteins is essential for normal embryonic development and crucial for the homeostasis of adult tissues. Aberrant Hh signaling has been implicated in a number of cancers, including ovarian cancer. Sonic Hedgehog (Shh) is the best studied of the Hh proteins, with a well-characterized signaling pathway that involves binding to the receptors Patched 1 and Patched 2. This signaling pathway is activated in basal cell carcinomas and other tumor types.
UC Berkeley researchers have made a cell line mutant for all alleles of Patched 1 and Patched 2. This cell line provides a means to identify agents targeting the Hh pathway, as well as a means to test therapeutics.
- *IP Issue Date
- Feb 2, 2017
- *Principal Investigator
-
Name: Henk Roelink
Department:
- Country/Region
- USA
