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Mouse Cell Lines Mutant For Patched 1 And Patched 2

技术优势: Ability to screen for agents that specifically target downstream components of Hedgehog signaling pathwayAllows identification of agents that modulate Hedgehog pathway activity in a cell

技术应用: Screen for agents that target the Hedgehog signaling pathwayTest therapeutics targeting the Hedgehog signaling pathwayDevelopmental researchStem cell research

*Abstract: In mammals, the Hedgehog (Hh) family of proteins is essential for normal embryonic development and crucial for the homeostasis of adult tissues. Aberrant Hh signaling has been implicated in a number of cancers, including ovarian cancer. Sonic Hedgehog (Shh) is the best studied of the Hh proteins, with a well-characterized signaling pathway that involves binding to the receptors Patched 1 and Patched 2. This signaling pathway is activated in basal cell carcinomas and other tumor types.

UC Berkeley researchers have made a cell line mutant for all alleles of Patched 1 and Patched 2. This cell line provides a means to identify agents targeting the Hh pathway, as well as a means to test therapeutics.

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