AsiaIPEX is a one-stop-shop for players in the IP industry, facilitating IP trade and connection to the IP world. Whether you are a patent owner interested in selling your IP, or a manufacturer looking to buy technologies to upgrade your operation, you will find the portal a useful resource.

Back to search results

Mi-6, A Hybridoma Secreting Monoclonal Antibody That Binds To Mouse Nkg2d

Technology Benefits: Does not crossreact with other tested receptors including NKG2A, B, C, & E.

Technology Application: Useful for detecting NKG2D cell surface expression.Can be used in vivo to block NKG2D-ligand interactions without depleting NKG2D+ cells.

Detailed Technology Description: None

Others: Tech ID/UC Case
17402/2004-095-0

Related Cases
2004-095-0

*Abstract: Thid invention relates to the development of a rat monoclonal antibody (Rat IgG2a/lambda) that binds specifically to the mouse NKG2D stimulatory receptor expressed by NK cells, activated CD8+ T cells, a subset of NK1.1+ T cells, and a subset of gama delta T cells. In cell culture, the antibody stimulates the receptor when in a crosslinking form, and blocks the receptor when in a soluble form. In vivo, the antibody does not deplete NKG2d+ cells ro strongly downmodulate it, but does block NKG2D-ligand interactions.

Reference:

Jamieson, A.M. & et al. 2002. the role of the NKG2D Immunoreceptor in Immume Cell Activation and Natural Killiing. Immunity. 17:19-29

*Principal Investigator: Name: David Raulet
Department:

Country/Region: USA

For more information, please click Here