Mi-6, A Hybridoma Secreting Monoclonal Antibody That Binds To Mouse Nkg2d
- 技術優勢
- Does not crossreact with other tested receptors including NKG2A, B, C, & E.
- 技術應用
- Useful for detecting NKG2D cell surface expression.Can be used in vivo to block NKG2D-ligand interactions without depleting NKG2D+ cells.
- 詳細技術說明
- None
- *Abstract
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Thid invention relates to the development of a rat monoclonal antibody (Rat IgG2a/lambda) that binds specifically to the mouse NKG2D stimulatory receptor expressed by NK cells, activated CD8+ T cells, a subset of NK1.1+ T cells, and a subset of gama delta T cells. In cell culture, the antibody stimulates the receptor when in a crosslinking form, and blocks the receptor when in a soluble form. In vivo, the antibody does not deplete NKG2d+ cells ro strongly downmodulate it, but does block NKG2D-ligand interactions.
Reference:
Jamieson, A.M. & et al. 2002. the role of the NKG2D Immunoreceptor in Immume Cell Activation and Natural Killiing. Immunity. 17:19-29
- *Principal Investigation
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Name: David Raulet
Department:
- 其他
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Tech ID/UC Case
17402/2004-095-0
Related Cases
2004-095-0
- 國家/地區
- 美國
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