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Parathyroid hormone derivative for treatment of osteoporosis

Summary: Hesham Tawfeek, M.D.

Technology Benefits: Effectively increases bone mass in mice.Does not induce osteoclast formation in cell culture.Weaker extra-skeletal side effects than PTH (1-34).Smaller peptide is easier to synthesize.Patent information:Patent Pending Tech Ventures Reference: IR CU13330

Technology Application: Treatment for diseases in which bone formation is beneficial, such as osteoporosis.Cell culture methods to detect osteoclast formation can be used to study osteoclasts Could be developed for drug screens to identify bone anabolic peptides without osteoclast formation.Could also be modified to prolong duration of action and decrease frequency and change route of administration.

Detailed Technology Description: Hesham Tawfeek, M.D.

*Abstract: None

*Inquiry: Peter GolikovColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR: CU13330

*Principal Investigator

*Publications: H Tawfeek, B Bedi, JY Li, J Adams, et al. Disruption of the PTH receptor 1 in T cells protects against PTH-induced bone loss. PLOSone, Vol 5, Issue 8, Aug 2010.

Country/Region: USA

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