Parathyroid hormone derivative for treatment of osteoporosis
- 總結
- Hesham Tawfeek, M.D.
- 技術優勢
- Effectively increases bone mass in mice.Does not induce osteoclast formation in cell culture.Weaker extra-skeletal side effects than PTH (1-34).Smaller peptide is easier to synthesize.Patent information:Patent Pending Tech Ventures Reference: IR CU13330
- 技術應用
- Treatment for diseases in which bone formation is beneficial, such as osteoporosis.Cell culture methods to detect osteoclast formation can be used to study osteoclasts Could be developed for drug screens to identify bone anabolic peptides without osteoclast formation.Could also be modified to prolong duration of action and decrease frequency and change route of administration.
- 詳細技術說明
- Hesham Tawfeek, M.D.
- *Abstract
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None
- *Inquiry
- Peter GolikovColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu
- *IR
- CU13330
- *Principal Investigation
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- *Publications
- H Tawfeek, B Bedi, JY Li, J Adams, et al. Disruption of the PTH receptor 1 in T cells protects against PTH-induced bone loss. PLOSone, Vol 5, Issue 8, Aug 2010.
- 國家/地區
- 美國
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