AsiaIPEX is a one-stop-shop for players in the IP industry, facilitating IP trade and connection to the IP world. Whether you are a patent owner interested in selling your IP, or a manufacturer looking to buy technologies to upgrade your operation, you will find the portal a useful resource.

Back to search results

PISA (Pyhin Protein Stimulating ASC) Triggers Inflammasome Activation in Response to Cytosolic B-DNA

Detailed Technology Description: This patented invention discloses methods for identification and compounds found to modulate the PISA receptor and it's downstream immune response. The innate immune system recognizes non-self genetic material and mounts a defensive immune response. However, self cytosolic DNA at times gets targeted and the process by which this phenomenon occurs

Countries: Not Available

Application No.: None

*Abstract: The innate immune system recognizes non-self genetic material and mounts a defensive immune response. However, self cytosolic DNA at times gets targeted and the process by which this phenomenon occurs has been largely unknown. The inventors have discovered PISA (PYHIN protein stimulating ASC), a receptor found to be necessary for activation of the ACS/caspase-1 axis of innate immunity in response to recognition of self cytosolic DNA.

*IP Issue Date: None

*IP Type: Other Patent

Country/Region: USA

For more information, please click Here