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PISA (Pyhin Protein Stimulating ASC) Triggers Inflammasome Activation in Response to Cytosolic B-DNA

详细技术说明

This patented invention discloses methods for identification and compounds found to modulate the PISA receptor and it's downstream immune response. The innate immune system recognizes non-self genetic material and mounts a defensive immune response. However, self cytosolic DNA at times gets targeted and the process by which this phenomenon occurs

*Abstract

The innate immune system recognizes non-self genetic material and mounts a defensive immune response. However, self cytosolic DNA at times gets targeted and the process by which this phenomenon occurs has been largely unknown. The inventors have discovered PISA (PYHIN protein stimulating ASC), a receptor found to be necessary for activation of the ACS/caspase-1 axis of innate immunity in response to recognition of self cytosolic DNA. 

*IP Issue Date

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*IP Type

Other Patent

国家

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申请号码

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国家/地区

美国