Tau C3 Monoclonal Antibody
- Technology Benefits
- The Tau C3 mAb, with its high affinity for the immunogen, is a powerful toolfor the detection of caspase cleaved tau in tissue and in solid phase assays .In addition to its use in tissue staining it may also be used for pull-downassays.The Tau C3 mAb was derived from a hybridoma cell line created through thefusion of SP2/o myeloma cells with splenocytes from a mouse immunized with apeptide corresponding the the C-terminus of tau truncated as aspartic acid 421.The hybridoma cell line (IgG1 subtype) was subcloned four times and stored infrozen liquid nitrogen. Tau C3 is specific for tau truncated at aspartic acid421; it neither reacts with full length tau, nor does it react with other tauC-terminal truncations.
- Detailed Technology Description
- Tau C3, is a mouse monoclonal antibody (mAb) that binds to human tautruncated at aspartic acid 421 as demonstrated by ELISA and immunoblot assays
- *Abstract
-
A new antibody specific for caspase cleaved Tau was developed at Northwestern University. The antibody stains amyloid beta treatedneurons and brain tissue in Alzheimer's disease, more specifically it stains asubset of neurofibrillary tangles, tau-containing neuritic plaques and neuropilthreads.
- *Inventors
- Lester Binder
- Country/Region
- USA
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