Compounds of the invention demonstrate high nAChR subtype selectivityThe 10-cytisine derivatives are significantly more lipophilic than cytisine, and thus more readily penetrate the BBB.
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Project ID: D2018-47 Background In many populations, salt intake is greater than the recommended 3.75 grams per day.Excess salt consumption can lead to cardiovascular, renal, and liver problems, including high blood pressure. Exercise can naturally decrease hypertension, but can be difficult for so.....
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This novel class of anti-fungal agents presents a new tool to fight strains resistant to common treatments, for example flucanazole. Such resistance constitutes a growing problem.New therapies are also in demand, because some anti-fungal treatments, such as amphotericin B have toxicity problems, esp.....
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