Our researchers have discovered that two key proteins, the dopamine D2 receptor (D2R) and the protein “disrupted in schizophrenia 1” (DISC1), form a protein‐protein interaction complex which has been shown to contribute to the pathophysiology of schizophrenia. Through the characterization of the pro.....
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Our scientists have identified a coupling between two functionally distinct dopamine receptors (D1 and D2) as a novel target for treatment of depression. Through the characterization of the protein‐protein receptor interaction we have developed a small peptide that selectively interferes with this c.....
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Our scientists have identified a protein-protein coupling between the α7 nicotinic acetylcholine receptor (α7nAChR) and the NR2A subunit of the N‐methyl‐D‐aspartate (NMDA) glutamate receptor as a novel target for treatment of nicotine and alcohol addiction. By characterizing the receptor‐receptor in.....
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Shih-Fu Chang, Ph.D.
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