The inventors have described methods for modulating bone formation andmineralization that can be used for the treatment of numerous bone-relateddisorders.
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Treatment of disorders associated with protein misfolding and/or aggregationDrug screening
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This invention allows treatment of non-allergic childhood asthma and similar conditions with compounds that increase de novo sphingolipid synthesis. This includes inhibitors of cystic fibrosis transmembrane conductance regulator (CFTR), inhibitors of dihydroceramide reductase and other agents that i.....
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