Alkylating agents are the most widely used anticancer drugs. Drug resistance is a major obstacle in the successful treatment of cancer by alkylating agents. The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) has been implicated in resistance of human tumors to alkylating agents. .....
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Novel approach for the treatment of Cytomegalovirus (CMV) infection. The technology addresses unmet medical need in the field of CMV management. The use of currently available anti-CMV drugs is limited due to toxicity, low oral bioavailability and drug resistance.We have a pre- clinical proof of co.....
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Female mice are fed with diets rich in specific f.a. (saturated or unsaturated) during pregnancy and/or lactation. The offspring is raised on a regular diet or on a fat rich diet, and develops obesity, fatty liver, and insulin resistance, depending on the diet received in utero. The model allows stu.....
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