ER stress, elicited by chemotherapeutic agents such as doxorubicin, 5FU, vincristine and bortezomib, or statins such simvastatin, triggers cell death at least in part through generation of leukotriene C4 (LTC4), which induces ROS accumulation, DNA damage and subsequent cell death. LTC4 can be produc.....
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LV Track is a decision support system for routine quantitative evaluation of LV function. Our proprietary algorithm enables fast and accurate analysis of echocardiographic cine loops for automatic extraction of LV parameters.• A basic prototype of the system (MATLAB) has been developed.• The system .....
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Although early programs targeting MMPs (matrix metalloproteins) were largely unsuccessful due to adverse side effects, they remain a viable and highly desirable therapeutic target. The main obstacle in the attempts to target MMPs is the ability to selectively target individual family members. The pr.....
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EG-30: clinical phase drug for AMD and Glaucoma EG-30 – the highlights: · Excellent safety profile in healthy volunteers and glaucoma patients• Low systemic exposure• No increase in IOP in glaucoma patients treated with EG-30 for 16days (eye drops)· Extensive safety a.....
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Highlights:Enables the preparation of stable, multi-use remote sensors for detection systems for environmental impurities Based on the introduction of indicator dyes into a novel composite glass film from which sensitive waveguides are fabricated Uses a plurality of nanopores sized between 20 and 20.....
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