Controlled drug delivery systems offer numerous advantages compared to conventional dosage forms including improved efficacy, reduced toxicity, and improved patient compliance and convenience. Controlled release systems aim to improve the effectiveness of drug therapy. This improvement can take the.....
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A universal computational framework for identifying molecular pathways underlying cancer viability and resistance. Our approach is applied to mining large collections of cancer patients’ data and identifying classes of genetic interactions termed synthetic lethality (SL). Synthetic lethality - The d.....
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Highlights:The World Health Organisation predicts that by 2040, as a result of a growing ageing population, neurodegenerative diseases (NDDs) will have overtaken cancer to become the world’s second leading cause of death, after cardiovascular disease. However, governments and industry have yet to ma.....
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ER stress, elicited by chemotherapeutic agents such as doxorubicin, 5FU, vincristine and bortezomib, or statins such simvastatin, triggers cell death at least in part through generation of leukotriene C4 (LTC4), which induces ROS accumulation, DNA damage and subsequent cell death. LTC4 can be produc.....
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