Inventors at UC San Diego have patented a method for optimizing therapeutic efficacy of treatment in a subject diagnosed with generalized social anxiety disorder. The method includes determining a subject's serotonin transporter gene promoter polymorphism genotype, correlating the subject's sero.....
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A series of novel lipid derivatives of phosphonate compounds has been synthesized. These novel compounds have been shown to promote oral uptake and increase delivery of the conjugate to the lung in animal models when compared with the parent compounds. A similar derivatization strategy can also be a.....
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Four novel compounds are undergoing a toxicology study with a mouse model of RSV infection.
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MSNPs constitute an efficient multifunctional platform with unique advantages in cargo delivery (e.g. DNA/siRNA, small molecule), targeting, controlled release, and bio-imaging. Advantages of using MSNP to deliver siRNA and anticancer drugs include the following: Mesoporous silica .....
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The NPS receptor may be used as a system to assay for agonists that are useful therapeutic agents in narcolepsy, hypersomnia or under conditions when elevated alertness is required. Antagonists to the NPS receptor may also be assayed for novel therapeutic approach to treat insomnia. NPS may also .....
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