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Method to Predict Treatment Response in Generalized Social Phobia

Detailed Technology Description

Inventors at UC San Diego have patented a method for optimizing therapeutic efficacy of treatment in a subject diagnosed with generalized social anxiety disorder. The method includes determining a subject's serotonin transporter gene promoter polymorphism genotype, correlating the subject's serotonin transporter gene promoter polymorphism genotype with a probability of being a positive responder or poor responder to therapy with a serotonin reuptake inhibitor, and selecting a drug for treatment based on the correlation. The method will assist physicians in making treatment decisions for individual patients with the disorder.

Supplementary Information

Patent Number: US8026059B2
Application Number: US2008279178A
Inventor: Stein, Murray B. | Gelernter, Joel
Priority Date: 15 Feb 2006
Priority Number: US8026059B2
Application Date: 22 Apr 2009
Publication Date: 27 Sep 2011
IPC Current: C12Q000168
US Class: 43500611 | 435006
Assignee Applicant: The Regents of the University of California
Title: Treatment response in generalized social phobia
Usefulness: Treatment response in generalized social phobia
Summary: The methods are useful for determining a response profile to treatment with a SRI in a subject diagnosed with generalized social anxiety disorder, determining whether to treat or continue treatment of a subject diagnosed with generalized social anxiety disorder with a serotonin reuptake inhibitor, and optimizing therapeutic efficacy of treatment in a subject diagnosed with generalized social anxiety disorder.
Novelty: Determining response profile to treatment with serotonin reuptake inhibitor (SRI) in a subject diagnosed with generalized social anxiety disorder by determining the subject's serotonin transporter gene promoter polymorphism genotype