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New Drug Derivatives for Promoting Oral Delivery to the Lung

Detailed Technology Description

A series of novel lipid derivatives of phosphonate compounds has been synthesized. These novel compounds have been shown to promote oral uptake and increase delivery of the conjugate to the lung in animal models when compared with the parent compounds. A similar derivatization strategy can also be applied to non-phosphonate compounds making this approach applicable to a variety of existing drugs. Drugs that have been modified in this way will very likely be more effective against diseases of the lung and this approach has the potential to improve the efficacy of drugs that are directed against pulmonary infections, such as influenza, or lung diseases, such as cancer.

Supplementary Information

Patent Number: US8101745B2
Application Number: US2007793276A
Inventor: Hostetler, Karl Y. | Beadle, James R.
Priority Date: 16 Dec 2004
Priority Number: US8101745B2
Application Date: 25 Apr 2008
Publication Date: 24 Jan 2012
IPC Current: C07H001906 | C07H001916
US Class: 5360261 | 5360267 | 5360268
Assignee Applicant: The Regents of the University of California
Title: Lung-targeted drugs
Usefulness: Lung-targeted drugs
Summary: (I) is useful for the treatment, prevention or amelioration of symptoms of lung disease such as lung cancer or lung infection (claimed). (I) is also useful for the treatment of viral, bacterial or fungal infections or small cell or non-small cell lung cancers.
Novelty: New conjugate comprising a drug covalently linked to a highly hydrophobic glycerol ether, useful for the treatment, prevention or amelioration of symptoms of lung disease such as lung cancer and lung infection

Industry

Disease Diagnostic/Treatment

Sub Category

Cancer/Tumor

Application No.

8101745

Others

Additional Technologies by these Inventors

• Derivatives of Novel Nucleoside Phosphonates with Anti-viral Activity
• New Derivatives of Phosphonate Compounds with Enhanced Anti-viral Activity
• New Antiviral Compounds

Tech ID/UC Case

19494/2004-258-0

Related Cases

2004-258-0

*Abstract

None

*IP Issue Date

Jan 24, 2012

*Principal Investigator

Name: James Beadle

Department:

Name: James Beadle

Department:

Name: Karl Hostetler

Department:

Name: Karl Hostetler

Department:

Country/Region

USA