RNAi responses have great potential to treat human disease, especially cancer and viral infections. However, siRNAs are macromolecules with no bioavailability to enter cells and require a delivery agent. Here we developed RNAi-molecules delivered into cells by the TAT Peptide Transduction Domain (.....
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This invention provides the first evidence that Hsp90 plays an active role in CLL progression/prognosis. Inhibiting Hsp90 or ZAP-70 activity or disrupting the interaction between the two molecules directs otherwise resistant cells to undergo apoptosis. Hsp90 inhibitors (proprietary or those .....
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• Diagnostic imaging in stroke, carotid occlusion, and cerebral ischemia • Image based guidance for intra-arterial treatment of stroke • Risk assessment for stroke • Evaluation of blood supply to tumors • Evaluation of blood supply to organ transplants such as kidneys • Evaluation of collateral bloo.....
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This invention relates to peptide analogs of corticotropin-releasing hormone and their use for treatment of proliferative disorders of the skin and other tissues.
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Proof of concept that FGFR2b can be used to isolate lung stem cells and that FGFR2b signaling is important for lung stem cell activation and therefore epithelial regeneration, tumor development as well as mucous cell hyperplasia.
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