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Derivatives of Novel Nucleoside Phosphonates with Anti-viral Activity

Detailed Technology Description

A series of novel nucleoside phosphonates with unique side chains has been synthesized. Derivatives of the novel phosphonates have been shown to have broad-spectrum antiviral activity when tested in cell culture assays against a variety of viruses, including herpes simplex virus-1, vaccinia virus, human cytomegalovirus, cowpox virus and hepatitis B virus. The new phosphonates may also provide an improved safety profile when compared to existing nucleoside phosphonates and their derivatives with antiviral activity could potentially be developed into drugs for the treatment of a range of viral diseases.

Supplementary Information

Patent Number: US8222257B2
Application Number: US2007887502A
Inventor: Hostetler, Karl Y. | Beadle, James R. | Choo, Hyunah
Priority Date: 1 Apr 2005
Priority Number: US8222257B2
Application Date: 14 Jan 2009
Publication Date: 17 Jul 2012
IPC Current: A01N004354 | A01N004390 | A61K0031505 | A61K003152 | A61K0031522 | C07D022502 | C07D023902 | C07D024500 | C07D047300 | C07D047500 | C07D048700 | C07F000902
US Class: 514256 | 5142581 | 5142632 | 5142633 | 51426337 | 5142634 | 514269 | 514274 | 540460 | 540463 | 540473 | 544243 | 544256 | 544264 | 544265 | 544272 | 544276 | 544277 | 544298 | 544322 | 544334
Assignee Applicant: The Regents of the University of California
Title: Phosphono-pent-2-en-1-yl nucleosides and analogs
Usefulness: Phosphono-pent-2-en-1-yl nucleosides and analogs
Summary: (IA) and (IB) are used in pharmaceutical composition, medicament, or article of manufacture for treating, preventing, or ameliorating viral infection (e.g. caused by influenza, hepatitis B (preferably drug resistant), hepatitis C, cytomegalovirus, varicella zoster, herpes simplex, Epstein-Barr virus, herpes types 6 and 8, retroviral infections, orthopoxviruses, vaccinia, ebola virus, adenovirus and papilloma virus) or growing neoplasm, for modulating cell proliferation, for treating cancer (lung cancer, head and neck squamous cancers, colorectal cancer, prostate cancer, breast cancer, acute lymphocytic leukemia, adult acute myeloid leukemia, adult non Hodgkin's lymphoma, brain tumors, cervical cancers, childhood cancers, childhood sarcoma, chronic lymphocytic leukemia, chronic myeloid leukemia, esophageal cancer, hairy cell leukemia, kidney cancer, liver cancer, multiple myeloma, neuroblastoma, oral cancer, pancreatic cancer, primary central nervous system lymphoma, and skin cancer), and for the treatment of cell proliferative disease (claimed).
Novelty: Novel 5-phosphono-pent-2-en-1-yl nucleoside bases and their derivatives are used for treatment, prevention, or amelioration of medical disorders associated with viral infections and/or cell proliferation

Industry

Disease Diagnostic/Treatment

Sub Category

Cancer/Tumor

Application No.

8222257

Others

Additional Technologies by these Inventors

• New Drug Derivatives for Promoting Oral Delivery to the Lung
• New Derivatives of Phosphonate Compounds with Enhanced Anti-viral Activity
• New Antiviral Compounds

Tech ID/UC Case

19684/2005-105-0

Related Cases

2005-105-0

*Abstract

None

*IP Issue Date

Jul 17, 2012

*Principal Investigator

Name: James Beadle

Department:

Name: James Beadle

Department:

Name: Hyunah Choo

Department:

Name: Karl Hostetler

Department:

Name: Karl Hostetler

Department:

Country/Region

USA