E. coli C1 strain for Intramammary Sensitization of Dairy Cows
- Detailed Technology Description
- The disclosure relates to a bacterial ghost E. coli C1 used for intramammary sensitization that may improve theoutcome of an intramammary infection in late gestation.
- Others
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- *Abstract
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Clinical Mastitis is one of the most common and very costly challengesto the dairy industry. Approximately 40% of clinical mastitis cases areattributed to gram-negative, mostly coliform, bacterial infection.
In a randomized controlled study, Cornell researchers have used aUV-killed strain C1 of E. coli for intramammarysensitization of dairy cows. Their vaccination strategy using this strainresulted in a lower probability of infection, a lower bacteria count, lowersomatic cell counts and milk conductivity, a lower clinical mastitis score,increased milk production and a triggered mucosal immunity in the mammarygland.
PotentialApplications
- Canbe used to protect against late gestation intramammary infection in dairy cows;
- Canbe used for challenge studies with the homologous E. coli C1 strain.
Advantages
- Lowerprobability of infection;
- Lowerbacteria count;
- Lowersomatic cell counts and milk conductivity;
- Lowerclinical mastitis score;
- Increasedmilk production;
- Triggered mucosalimmunity in the mammary gland.
- *Licensing
- Phillip Owhpo62@cornell.edu1-607-254-4508
- Country/Region
- USA
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